The human phenolsulphotransferase polymorphism is determined by the level of expression of the enzyme protein.
نویسندگان
چکیده
We have examined the expression of platelet phenolsulphotransferase (PST) in 60 individuals. Using an antibody which recognizes both forms of PST present in man (P-PST and M-PST), we determined that the polymorphism of platelet P-PST activity is determined by the level of expression of the enzyme protein. The implications for susceptibility to adverse drug reactions and chemical carcinogenesis are discussed.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 296 ( Pt 2) شماره
صفحات -
تاریخ انتشار 1993